BDBM50383191 CHEMBL2031893

SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3F)c2cc1OC

InChI Key InChIKey=SBLMCLDRWJNEJK-UHFFFAOYSA-N

Data  4 KI  36 IC50

PDB links: 2 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50383191   

TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataKi:  1nMAssay Description:Inhibition of recombinant c-met-mediated gastrin phosphorylation by HTRF assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50:  10nMAssay Description:Inhibition of VEGFR2 by HTRF assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50:  20nMAssay Description:Inhibition of HGF-mediated c-Met autophosphorylation in human PC3 cells after 10 mins by quantitative electrochemiluminescent immunoassayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50:  1nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50:  1nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50:  10nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50:  10nMAssay Description:Inhibition of VEGFR2 by HTRF assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50:  10nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50:  20nMAssay Description:Inhibition of HGF-mediated c-met autophosphorylation in serum-starved human PC3 cells after 1 hr by electrochemiluminescent immunoassayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50:  1nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50383191(CHEMBL2031893)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair